Join our high-performing Oligonucleotide Production team in Southampton—a vibrant coastal city offering the perfect balance of professional opportunity and quality of life, with excellent transport links.

We are seeking a Senior Scientist with deep expertise in downstream processing modalities including oligonucleotides/Peptides to lead analytical strategy and contribute to the development and production of high-quality modified Oligonucleotides

Key responsibilities

• Lead and oversee downstream workflows, supporting purification, analysis and characterisation of oligonucleotides including HPLC, SDS-PAGE, TFF and UPPL-MS

• Stay abreast of emerging technologies and methodologies in nucleic acid chemistry

• Drive method development and troubleshooting with purification techniques

• Ensure rigorous documentation

• Collaborate cross functionally across the organisation

• Coach and mentor junior team members

Skills and Experience

• PhD in Chemistry and/or related discipline

• Proven hands-on experience working with oligonucleotides/peptides is highly desirable within Academia or Industry (Small molecule experience will also be considered)

• Experience of UF/DF and TFF is highly desirable

• Strong background in purification and downstream processing techniques - HPLC, UPLC-MS, SDS-PAGE

• Experience working in ISO/GMP regulated environments is highly desirable

• Self-starter with the ability to lead projects which require troubleshooting and problem solving

• Detail orientated, strong communicator who can work under pressure in a fast-changing environment

What we can offer you:

• 25 days annual leave plus 8 paid bank holidays

• Contributory pension scheme (6% employer contribution)

• Flexible working hours

• Life Assurance (x4 salary)

• Long service awards

• Reward and recognition scheme

• Employer Assistance Programme with 24/7 remote GP service

• Annual flu jabs

• Cycle to work scheme

• Corporate discount on gym membership

• Savings and discounts

• Reimbursement of professional membership fees

• Referral incentives

• Social events

• Volunteering days

Biotage is a global supplier and solutions partner to a wide range of customers within drug discovery and development and analytical testing. With strong expertise in separation and purification technologies, and a focus on leveraging intelligent workflow solutions, we aim to efficiently support the advancement and protection of human health. Learn more at biotage.com